TRAF-type zinc finger domain-containing protein 1 (protein FLN29, RAFD1, FLN29)

Function

• lipopolysaccharide (LPS)-inducible negative regulator in innate immunity
• role in endotoxin tolerance
• negative regulator in toll-like receptor signaling
• interacts with TRAF6

Structure

contains 1 TRAF-type zinc finger

Expression

• LPS, IFNB1 and IFNG increase protein levels in RAW cells, IFNB1 is the most potent inducer
• IL4 & IL10 do not induce expression in RAW cells
• LPS does not induce expression in the presence of IL4 or IL10

More general terms

• zinc finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O14545.html