DNA cross-link repair 1A protein (hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A)

Function

• may be required for DNA interstrand cross-link repair
• required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons
• binds constitutively to TP53BP1
• binds CDC27, which is itself a component of the anaphase promoting complex
• binds PIAS1

Structure

• belongs to the DNA repair metallo-beta-lactamase (DRMBL) family

Compartment

• nucleus
• in some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1
• found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents, these foci overlap with those formed by the MRN complex & BRCA1

Expression

• expressed in brain, heart, kidney, liver, pancreas, placenta, skeletal muscle
• induced during mitosis mRNA encoding this protein contains an internal ribosome entry site (IRES) in its 5'-UTR that generally suppresses translation while specifically promoting expression during mitosis, when cap-dependent translation may be impaired

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6PJP8.html