histone H2B type 2-D (HIST2H2BD)

Function

• histone H2B
• phosphorylation on Ser-14 by STK4/MST1 during apoptosis facilitates apoptotic chromatin condensation
• phosphorylated on Ser-14 in response to DNA double-strand breaks (DSBs) & in conection with somatic hypermutation & immunoglobulin class-switch recombination

Structure

• in contrast to other H2B histones, does not contain conserved residue in C-terminus that is target of monoubiquitination
• belongs to the histone H2B family

Compartment

nucleus

Genetics

• mouse orthologous protein seems not to exist
• could be the product of a pseudogene

More general terms

• histone-H2B
• phosphoprotein
• evolutionary divergent protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6DRA6.html