histone H2B type 2-C (H2.t, H2B/t, HIST2H2BC)

Function

• histone H2B
• phosphorylated on Ser-14 by STK4/MST1 during apoptosis
• may facilitate apoptotic chromatin condensation
• phosphorylated on Ser-14 in response to DNA double-strand breaks, & in connection with somatic hypermutation & immunoglobulin class-switch recombination

Structure

• in contrast to other H2B histones, does not contain conserved residue in C-terminus that is target of monoubiquitination
• belongs to the histone H2B family

Compartment

nucleus, chromosome

Genetics

• mouse orthologous protein seems not to exist
• could be the product of a pseudogene

More general terms

• histone-H2B
• evolutionary divergent protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6DN03.html