histone H2B type 2-F (HIST2H2BF)

Function

• monoubiquitination of Lys-120 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation & is also prerequisite for histone H3 Lys-4 & Lys-79 methylation
• cooperates with FACT dimer to stimulate elongation by RNA polymerase 2
• phosphorylated on Ser-14 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation
• phosphorylated on Ser-14 in response to DNA double strand breaks (DSBs) & in correlation with somatic hypermutation & immunoglobulin class-switch recombination

Structure

belongs to the histone H2B family

Compartment

nucleus

More general terms

• histone-H2B
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5QNW6.html