Dual adapter for phosphotyrosine & 3-phosphotyrosine & 3-phosphoinositide (hDAPP1, B cell adapter molecule of 32 kD, B lymphocyte adapter protein Bam32, DAPP1, BAM32, HSPC066)

Function

• B-cell-associated adapte
• regulates B-cell antigen receptor-signaling downstream of PI3K
• interacts with PIP3 & PLCG2
• in vitro, interacts with PtdIns(3,4)P2
• phosphorylated on Tyr

Structure

• contains 1 PH domain
• contains 1 SH2 domain

Compartment

• cytoplasm, peripheral membrane
• membrane-associated after cell stimulation leading to its translocation

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, lung > brain, heart, kidney, liver, pancreas, skeletal muscle
• expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic blood cells
• induced upon B-cell activation

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605768
• UniProt: http://www.uniprot.org/uniprot/Q9UN19.html