zinc finger protein 638; cutaneous T-cell lymphoma-associated antigen se33-1; CTCL-associated antigen se33-1; nuclear protein 220; zinc finger matrin-like protein (ZNF638, NP220, ZFML)

Function

• early regulator of adipogenesis
  • transcription cofactor of CEBPs, controlling expression of PPARG & probably of other proadipogenic genes, such as SREBF1
• binds to cytidine clusters in double-stranded DNA
• interacts with FHL2
• interacts with CEBPA, CEBPD & CEBPG (putative)

Structure

• contains 1 matrin-type Zn+2 finger
• contains 2 RRM domaind (RNA recognition motifd)

Compartment

nuclear, in nuclear speckles

Alternative splicing

named isoforms=5

Expression

• broadly expressed

Pathology

• isoform 5 is a tumor-associated antigen found in cutaneous T-cell lymphoma
  • mycosis fungoides
  • Sezary syndrome

More general terms

• zinc finger protein
• phosphoprotein
• DNA-binding protein

Additional terms

• cutaneous T-cell lymphoma (CTCL)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27332
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27332
• OMIM: https://mirror.omim.org/entry/614349
• UniProt: http://www.uniprot.org/uniprot/Q14966.html