epidermal growth factor (EGF) receptor kinase substrate 8-like protein 2; EPS8-like protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-related protein 2 (EPS8L2, EPS8R2, PP13181)

Function

• stimulates guanine exchange activity of SOS1
• membrane ruffling
• remodelling of the actin cytoskeleton
• interacts with ABI1, F-actin
• component of complex that contains SOS1, ABI1, EPS8L2

Structure

• belongs to the EPS8 family
• contains 1 PID domain
• contains 1 SH3 domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• detected in fibroblasts & placenta

More general terms

• epidermal growth factor receptor kinase substrate 8-like protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64787
• UniProt: http://www.uniprot.org/uniprot/Q9H6S3.html