Wilms' tumor 1-associating protein; pre-mRNA-splicing regulator WTAP; Female-lethal(2)D homolog; hFL(2)D; WT1-associated protein (WTAP KIAA0105)

Function

• regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability
• impairs WT1 DNA-binding ability & inhibits expression of WT1 target genes
• may be involved in mRNA splicing regulation
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with WT1

Structure

belongs to the fl(2)d family

Compartment

nucleus, nucleolus

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• in smooth muscle cells, up-regulated after serum withdrawal, when cells become mature & non proliferative

More general terms

• splicing factor; snRNP-associated protein
• phosphoprotein

Additional terms

• Wilm's tumor; nephroblastoma
• Wilms' tumor protein; WT1 protein (WT1, WT3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9589
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9589
• OMIM: https://mirror.omim.org/entry/605442
• UniProt: http://www.uniprot.org/uniprot/Q15007.html