Golgin subfamily A member 5; cell proliferation-inducing gene 31 protein; Golgin-84; protein Ret-II; RET-fused gene 5 protein (GOLGA5, RETII, RFG5, PIG31)

Function

• role in maintaining Golgi structure
• stimulates the formation of Golgi stacks & ribbons
• involved in intra-Golgi retrograde transport
• highly phosphorylated during mitosis
• phosphorylation is barely detectable during interphase
• interacts with RAB1A that has been activated by GTP-binding, & possibly also with OCRL1
• interacts with isoform CASP of CUX1

Structure

• homodimer

Compartment

• Golgi apparatus membrane
• single-pass type 4 membrane protein
• found throughout the Golgi
  • cisternae
  • higher levels on the tubulo-vesicular structures of the cis-Golgi network

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• highly expressed in seminiferous tubules & Leydig cells in testis
• detected at much lower levels in the other tissues
• expression is very low or not detectable in spermatozoa

Pathology

• translocation t(10;14)(q11;q32) with RET is a cause of papillary thyroid carcinoma

More general terms

• golgin (GOLGI autoantigen)
• phosphoprotein

Additional terms

• papillary thyroid carcinoma

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9950
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9950
• OMIM: https://mirror.omim.org/entry/188550
• OMIM: https://mirror.omim.org/entry/606918
• UniProt: http://www.uniprot.org/uniprot/Q8TBA6.html