ret proto-oncogene

Introduction

10q11.2

Expression

at least four different transcripts

Pathology

• loss of function mutations in the ret gene induces Hirschsprung's disease
• in contrast, activating mutations in the ret gene are associated with multiple endocrine neoplasia types 2A & 2B & familial medullary thyroid carcinoma, & 20-30% of papillary thyroid carcinomas

More general terms

• proto-oncogene

Additional terms

• familial medullary thyroid carcinoma
• Hirschsprung disease; congenital megacolon; colonic aganglionosis; aganglionic megacolon
• multiple endocrine neoplasia type-2 (MEN-2)
• papillary thyroid carcinoma

Database

• OMIM: https://mirror.omim.org/entry/164761
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5979