splicing factor 3B subunit 3 (spliceosome associated protein 130, SAP 130, SF3b130, pre-mRNA splicing factor SF3b 130 kD subunit, SF3B4)

Function

• subunit of the splicing factor SF3B
• identified in the spliceosome C complex
• SF3B associates with the splicing factor SF3A & a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP)
• SF3B2 interacts directly with SF3B4
• interacts with HIV-1 Vpr
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 1 SAP domain

Compartment

nucleus (putative)

More general terms

• splicing factor; snRNP-associated protein
• protein subunit
• phosphoprotein

Component of

• splicing factor 3B (SF3B)
• Sin3A corepressor complex
• spliceosome C complex

Database

• OMIM: https://mirror.omim.org/entry/605592
• UniProt: http://www.uniprot.org/uniprot/Q15393.html