redox repair function-1; DNA-(apurinic or apyrimidinic site) lyase; AP endonuclease-1; APEX nuclease (ref1)

Function

• repairs oxidative DNA damages in vitro
• role in oxidation/reduction of AP1
• DNA A/P endonuclease activity
• reduction of cysteines with DNA-binding domains of fos & jun stimulates AP1 DNA-binding activity
• role in protection against cell lethality & suppression of mutations (putative)
• removes the blocking groups from the 3'-termini of DNA str& breaks generated by ionizing radiations & bleomycin monomer
• component of the SET complex
• the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar & a product with a terminal 5'-phosphate

Structure

belongs to the DNA repair enzymes AP/exoA family

Compartment

nucleus

More general terms

• endodeoxyribonuclease
• metalloprotein

Component of

• SET complex

Database

• UniProt: http://www.uniprot.org/uniprot/P27695.html
• OMIM: https://mirror.omim.org/entry/107748
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=328