evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (protein SITPEC, ECSIT)

Function

• adapter protein of Toll-like & IL-1 receptor signaling pathway involved in the activation of NF-kappa-B via MAP3K1
• promotes proteolytic activation of MAP3K1
• involved in BMP signaling pathway
• required for normal embryonic development
• required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase
• interacts with MAP3K1, SMAD4 & TRAF6
• interacts with SMAD1 only after BMP4-treatment
• interacts with NDUFAF1

Structure

belongs to the ECSIT family

Compartment

cytoplasm, nucleus, mitochondrion

Alternative splicing

named isoforms=2

More general terms

• mitochondrial protein
• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/608388
• UniProt: http://www.uniprot.org/uniprot/Q9BQ95.html