protein IkappaBNS; T-cell activation NFKB-like protein; TA-NFKBH (IKBNS, NFKBID)

Function

• may regulate the expression of IL-2, IL-6, & other cytokines through regulation on NF-kappa-B activity
• functions in regulation of inflammatory responses
• may also regulate TCR- induced negative selection of thymocytes
• interacts with NFKB1, RELA & RELB; in the nucleus

Structure

contains 6 ANK repeats

Compartment

nucleus (putative)

Alternative splicing

named isoforms=3

More general terms

• nuclear protein
• ankyrin repeat domain protein (ANKRD)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8480
• UniProt: http://www.uniprot.org/uniprot/Q8NI38.html