transcription factor relB; I-rel (RELB)

Function

• component of the NF-kappa-B RelB-p50 complex
• component of the NF-kappa-B RelB-p52 complex
• self-associates; the interaction seems to be transient & may prevent degradation allowing for heterodimer formation with p50 or p52
• NF-kappa-B heterodimeric RelB-p50 & RelB-p52 complexes are transcriptional activators
• RELB neither associates with DNA nor with RELA/p65 or REL
• stimulates promoter activity in the presence of NFKB2/p49
• interacts with NFKB1/p50, NFKB2/p52 & NFKB2/p100
• interacts with IKBNS
• phosphorylation at Thr-103 & Ser-573 is followed by proteasomal degradation (putative)

Structure

• both N-terminal & C-terminal domains are required for transcriptional activation
• contains 1 RHD (Rel-like) domain

Compartment

nucleus

Expression

induced by mitogens

Notes

• originally thought to inhibit transcriptional activity of nuclear factor NF-kappa-B

More general terms

• rel protein family
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01201.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5971
• OMIM: https://mirror.omim.org/entry/604758
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5971