Ca+2/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein, CaM-KIIN) (CAMK2N2)

Function

• potent & specific cellular inhibitor of CaM-kinase 2 (CAMK2)
• traps Ca+2/calmodulin on CAMK2
• may play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells
• traps Ca+2/calmodulin on CAMK2
• interacts with CAMK2A & CAMK2B in the presence of Ca+2/calmodulin or after autophosphorylation (putative)

Structure

• inhibitory domain blocks CAMK2 binding to GRIN2B
• belongs to the CAMK2N family

Compartment

• nucleus
• cytoplasm, cytosol
• excluded from nucleus when coexpressed with activated CAMK2

Expression

• expressed in cell lines including hemopoietic cell lines & some tumor cell lines
• highly expressed in stimulated dendritic cells & weakly expressed in unstimulated mature & immature dendritic cells
• expressed in kidney, liver > heart, skeletal muscle, placenta > small intestine
• expressed in HeLa cell S3, lymphoblastic leukemia MOLT-4, & Burkitt's lymphoma Raji cells > chronic myelogenous leukemia K-562 cells > colorectal adenocarcinoma SW480, & lung carcinoma A549 cells

More general terms

• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9403
• OMIM: https://mirror.omim.org/entry/608721
• UniProt: http://www.uniprot.org/uniprot/Q96S95.html