Junction-mediating & -regulatory protein (JMY)

Function

• cofactor that increases p53/TP53 response via its interaction with p300/EP300
• increases p53/TP53-dependent transcription & apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage (putative)
• interacts with p300/EP300, the complex being recruited to activated p53/TP53
• interacts with TTC5 (putative)
• ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome
• in case of DNA damage, interaction with MDM2 is altered, preventing degradation & allowing interaction with p300/EP300 & its function in p53/TP53 stress response

Structure

contains 1 WH2 domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

induced by E2F

More general terms

• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1337
• OMIM: https://mirror.omim.org/entry/604279
• UniProt: http://www.uniprot.org/uniprot/Q8N9B5.html