zinc finger matrin-type protein 3 (zinc finger protein WIG-1, p53-activated gene 608 protein, ZMAT3, PAG608, WIG1)

Function

• acts as a bona fide target gene of p53
• may play a role in the p53-dependent growth regulatory pathway
• may contribute to p53-mediated apoptosis by regulation of p53 expression & translocation to the nucleus & nucleolus
• interacts with dsRNA

Structure

contains 3 matrin-type zinc fingers

Compartment

nucleus, nucleus, nucleolus

Expression

• expressed in adult brain > adult kidney & testis
• not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine
• induced by DNA damage (p53-dependent)
• up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung & in various colon cancer cell lines

More general terms

• nuclear protein
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/606452
• UniProt: http://www.uniprot.org/uniprot/Q9HA38.html