SERTA domain-containing protein 1 (transcriptional regulator interacting with the PHD-bromodomain 1, TRIP-Br1, CDK4-binding protein p34SEI1, SEI-1, SERTAD1, SEI1)

Function

• acts at E2F-responsive promoters to integrate signals of PHD- &/or bromodomain-containing transcription factors
• stimulates E2F-1/DP-1 transcriptional activity
• renders activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16INK4a
• interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B & p300/CBP
• binds to DP1
• interacts with CDK4

Structure

contains 1 SERTA domain

More general terms

• SERTA domain-containing protein (SERTAD)
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UHV2.html