TATA box-binding protein-associated factor RNA polymerase 1 subunit C (TATA box-binding protein-associated factor 1C, TBP-associated factor 1C, TBP-associated factor RNA polymerase I 110 kD, TAFI110, TAF1C)

Function

• component of the transcription factor SL1/TIFIB complex
• in the complex interacts directly with TBP, TAF1A & TAF1B.
• interacts with MYC, RRN3 & p53/TP53 with low affinity
• recruits RNA polymerase 1 to the rRNA gene promoter via interaction with RRN3

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• protein subunit
• nuclear protein

Component of

• transcription factor SL1/TIFIB complex

Database

• OMIM: https://mirror.omim.org/entry/604905
• UniProt: http://www.uniprot.org/uniprot/Q15572.html