RNA polymerase 1-associated factor PAF49 (anti-sense to ERCC-1 protein, ASE-1, CD3-epsilon-associated protein, CD3E-associated protein, CAST, CD3EAP, ASE1, CAST, PAF49)

Function

• initiation of rRNA transcription by RNA polymerase 1 holoenzyme
• isoform 2 described as a component of T-cell receptor complex*
  • may undergoes TYR phosphorylation upon TCR stimulation
• interacts with TAFI48 subunit of SL1 complex, PRAF1
• isoform 2 interacts with CD3E

Compartment

• nucleus
• found at the fibrillar centers of nucleolus in interphase
• localized to nucleolus organizer regions of the chromosomes during cell division

Alternative splicing

named isoforms=2

Genetics

• gene is in an antisense orientation to & overlaps the gene of DNA repair enzyme ERCC1; this gene overlap is conserved in mouse suggesting an important biologic function

* evidence favors rRNA transcription rather than T-cell receptor signaling

More general terms

• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/107325
• UniProt: http://www.uniprot.org/uniprot/O15446.html