polymerase delta interacting protein 3; 46 kD DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR (POLDIP3 KIAA1649 PDIP46)

Function

• role in regulation of translation
• preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation
• contributes to enhanced translational efficiency of spliced over nonspliced mRNAs
• recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA
• phosphorylated upon DNA damage, probably by ATM or ATR
• phosphorylated at Ser-383 & Ser-385 by RPS6KB1
• interacts with POLD2
• interacts with NCBP1 & EIF4A3
• associates with the multiprotein exon junction complex (EJC)
• interacts with RPS6KB1 (activated). interacts with ERH

Structure

contains 1 RRM domain (RNA recognition motif)

Compartment

• nucleus, nuclear speckle, cytoplasm
• nucleocytoplasmic shuttling protein

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• RNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84271
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84271
• OMIM: https://mirror.omim.org/entry/611520
• UniProt: http://www.uniprot.org/uniprot/Q9BY77.html