DNA repair protein REV1; alpha integrin-binding protein 80; AIBP80; Rev1-like terminal deoxycytidyl transferase (REV1, REV1L)

Function

• deoxycytidyl transferase
• involved in DNA repair
• transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction
• may assist in the first step in the bypass of abasic lesions by insertion of a nucleotide opposite the lesion
• required for normal induction of mutations by physical & chemical agents
• interacts with the DNA polymerase zeta
  • interaction with MAD2L2 is direct & requires that REV3L is in its closed conformation
• interacts with POLH, POLI & POLK
• may bind ITGA3

Structure

• monomer
• the C-terminal domain is necessary for protein interactions
• belongs to the DNA polymerase type-Y family
• contains 1 BRCT domain
• contains 1 umuC domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=3

Expression

ubiquitous

More general terms

• DNA nucleotidyltransferase
• phosphoprotein

Additional terms

• DNA repair

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51455
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51455
• OMIM: https://mirror.omim.org/entry/606134
• UniProt: http://www.uniprot.org/uniprot/Q9UBZ9.html