DNA polymerase zeta catalytic subunit (REV3L, POLZ REV3)

Function

• translesion DNA synthesis (putative)
• interacts with REV7
• component of DNA polymerase zeta

Structure

• homolog of S. cerevisiae REV3
• Its C-terminal part could serve as the catalytic domain during nucleotide polymerization
• its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis
• belongs to the DNA polymerase type-B family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• protein subunit
• zinc finger protein
• phosphoprotein

Component of

• DNA polymerase zeta

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5980
• OMIM: https://mirror.omim.org/entry/602776
• UniProt: http://www.uniprot.org/uniprot/O60673.html