Sp110 nuclear body protein; interferon-induced protein 41/75; speckled 110 kD; transcriptional coactivator Sp110 (SP110)

Function

• transcription factor
• may be a nuclear hormone receptor coactivator
• enhances transcription of genes with retinoic acid response elements (RARE)
• phosphorylated (isoform 2)
• isoform 3 interacts with HCV core protein

Structure

• contains 1 bromo domain
• contains 1 HSR domain
• contains 1 PHD-type Zn+2 finger
• contains 1 SAND domain

Compartment

• nucleus, found in the nuclear body

Alternative splicing

named isoforms=6

Expression

• expressed in peripheral blood leukocytes & spleen > thymus, prostate, testis, ovary, small intestine & colon > heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
• induced by IFNG/IFN-gamma & all-trans retinoic acid (ATRA)

Pathology

• defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency

More general terms

• zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3431
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3431
• OMIM: https://mirror.omim.org/entry/235550
• OMIM: https://mirror.omim.org/entry/604457
• UniProt: http://www.uniprot.org/uniprot/Q9HB58.html