calcineurin-binding protein cabin-1; calcineurin inhibitor; CAIN (CABIN1, KIAA0330)

Function

• may be required for replication-independent chromatin assembly
• may serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin
• binds to & inhibits phosphatase activity of calcineurin
• inhibition of activated calcineurin is dependent on both PKC & Ca+2 signals
• activated through PKC-mediated hyperphosphorylation
• phosphorylated upon DNA damage, probably by ATM or ATR
• component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 & UBN1
• interacts with calcineurin
• interacts with MEF2B

Structure

• contains 6 TPR repeats

Compartment

• nucleus

Expression

• widely expressed in different tissues

More general terms

• PEST protein
• nuclear protein
• calcineurin inhibitor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23523
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23523
• OMIM: https://mirror.omim.org/entry/604251
• UniProt: http://www.uniprot.org/uniprot/Q9Y6J0.html