nuclear receptor subfamily 4 group A member 2; orphan nuclear receptor NURR1; immediate-early response protein NOT; transcriptionally-inducible nuclear receptor (NR4A2, NOT, NURR1, TINUR)
Jump to navigation
Jump to search
Function
- probable nuclear receptor
- may function as a general coactivator of gene transcription
- detection of the protein in the brain, indicates that it is not mandatorily associated with cell cycle progression
- required for development of midbrain dopaminergic neurons
- can interact with DNA as monomer & forms heterodimers with RXR which binds to similar response elements as RAR-RXR
Structure
- belongs to the nuclear hormone receptor family, NR4 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
nucleus (probable)
Expression
- expressed in a number of cell lines of T-cell, B-cell & fibroblast origin
- strong expression in brain tissue
- expressed in neurons in substantia nigra pars compacta & ventral tegmentum
- encoded by immediate early gene
- rapidly & only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle
More general terms
- nuclear hormone receptor NR4 subfamily
- immediate early response protein
- zinc finger protein
- phosphoprotein
References
- ↑ UniProt http://www.uniprot.org/uniprot/P43354.html
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/NR4A2
- ↑ Zetterstrom RH et al Dopamine neuron agenesis in Nurr1-deficient mice. Science 276:248-9 1997 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9092472
- ↑ Zetterstrom RH et al Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol Brain Res 41:111-20 1996 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8883941