myeloid cell nuclear differentiation antigen (MNDA)

Function

• may act as a transcriptional activator/repressor in the myeloid lineage
• plays a role in the granulocyte/monocyte cell-specific response to interferon
• stimulates the DNA binding of the transcriptional repressor protein YY1
• participates in a ternary complex with YY1 & the YY1 target DNA element
• binds nucleolin & nucleophosmin/NPM/B23

Structure

• its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding & a portion of this sequence is responsible for binding YY1
• contains 1 DAPIN domain
• contains 1 HIN-200 domain

Compartment

• nucleus, cytoplasm
• uniformly distributed throughout the interphase cell nucleus
• associates with chromatin

Expression

• expressed constitutively in cells of the myeloid lineage
• found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes & granulocytes
• also appear in myeloblast cells in some cases of acute myeloid Leukemia
• strongly induced by alpha interferon which selectively affects expression in late stage cells in monocytic but not granulocytic lineage
• induced in vitro by 1,25 dihydroxyvitamin D3 & dimethylsulfoxide

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/P41218.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4332
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4332
• OMIM: https://mirror.omim.org/entry/159553