WAP, kazal, immunoglobulin, kunitz & NTR domain-containing protein 1 (WAP, follistatin, immunoglobulin, kunitz & NTR domain-containing protein, growth & differentiation factor-associated serum protein 2, GASP-2, hGASP-2, WFIKKN1, GASP2, WFIKKN, PSEC0040)
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Function
- protease-inhibitor
- contains multiple distinct protease inhibitor domains
- probably has serine protease- & metalloprotease-inhibitor activity
Structure
- belongs to the WFIKKN family
- contains 2 BPTI/Kunitz inhibitor domains 2nd BPTI/Kunitz inhibitor domain is able to inhibit trypsin; however, it has no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Kazal-like domain
- contains 1 NTR domain
- contains 1 WAP domain