histone-H2B.2; histone H2B type 1-O; H2B.n; H2B/n; (HIST1H2BO, H2BFH ,H2BFN)

Function

• histone 2B
• monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation & is also prerequisite for histone H3 Lys-4 & Lys-79 methylation
• functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase 2
• phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation
• phosphorylated on Ser-15 in response to DNA double-strand breaks, & in correlation with somatic hypermutation & immunoglobulin class-switch recombination

Structure

belongs to the histone H2B family

Compartment

nucleus

Genetics

• mouse orthologous protein seems not to exit

More general terms

• histone-H2B
• evolutionary divergent protein

Database

• UniProt: http://www.uniprot.org/uniprot/P23527.html