histone H2B type 1-D; histone-H2B.b; H2B.b; H2B/b; H2B.1 B; HIRA-interacting protein 2 (HIST1H2BD, H2BFB HIRIP2)

Function

• histone H2B
• monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation & is also prerequisite for histone H3 Lys-4 & Lys-79 methylation
• functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase 2
• phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation
• phosphorylated on Ser-15 in response to DNA double-strand breaks, & in correlation with somatic hypermutation & immunoglobulin class-switch recombination

Structure

belongs to the histone H2B family

Compartment

nucleus

Comparative biology

• mouse othologous protein seems not to exist

More general terms

• histone-H2B
• evolutionary divergent protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3017
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3017
• OMIM: https://mirror.omim.org/entry/602799
• UniProt: http://www.uniprot.org/uniprot/P58876.html