apo B mRNA-editing protein (HEPR, APOBEC1)
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Function
- catalytic subunit of apo-B mRNA editing complex involved in mRNA-editing of apolipoprotein B in small intestine
- apolipoprotein B mRNA editing results in the formation of apo B48, rather than apo B100
- postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA
- also involved in CGA (Arg) to UGA (stop) editing in the NF1 mRNA
- part of the apolipoprotein B mRNA editing complex with A1CF
- found in a complex with CUGBP2 & A1CF
- A1CF binds to APOB mRNA & is probably responsible for docking APOBEC1 to the mRNA
- interacts with HNRPAB & SYNCRIP
Structure
- homodimer.
- belongs to the cytidine & deoxycytidylate deaminase family
Expression
expressed exclusively in the small intestine
More general terms
Component of
References
- ↑ Hadjiagapiou C et al Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. Nucleic Acids Res 22:1874 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8208612
- ↑ Bhattacharya et al, Cytosine nucleoside/nucleotide deaminases and apolipoprotein B mRNA editing. TIBS 19:105 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8203015
- ↑ Scott et al Current Opinion In Lipidology 5:87 1994
- ↑ UniProt http://www.uniprot.org/uniprot/P41238.html