chromogranin-A; CgA; secretogranin-A; pituitary secretory protein I; SP-I; contains: vasostatin-1; vasostatin-2; EA-92; ES-43; pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37 (CHGA)
Jump to navigation
Jump to search
Function
- pancreastatin strongly inhibits glucose induced insulin release from the pancreas
- sulfated on Tyr &/or contains sulfated glycans
- O-glycosylated with core 1 or possibly core 8 glycans
- interacts with SCG3 (putative)
Structure
- belongs to the chromogranin/secretogranin protein family
Compartment
- cytoplasmic vesicle
- secretory vesicle lumen, secretory vesicle membrane (putative)
- secreted; associated with secretory granule membrane through interaction with SCG3 that in turn binds to cholesterol- enriched lipid rafts (putative)
Expression
- widespread distribution in endocrine organs
- originally found in adrenal medulla
- present in alpha cells of pancreatic islets
Notes
binds Ca+2 with a low-affinity
More general terms
More specific terms
References
- ↑ Huttner WB, Gerdes HH, Rosa P. The granin (chromogranin/secretogranin) family. Trends Biochem Sci. 1991 Jan;16(1):27-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053134
- ↑ Cetin Y et al Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2360-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8096340
- ↑ Ross CA, McInnis MG, Margolis RL, Li SH. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7689767
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1113
- ↑ UniProt http://www.uniprot.org/uniprot/P10645.html