secretogranin-3; secretogranin III; SgIII (SCG3)

Function

• interacts with CHGA (putative)

Compartment

• secreted
• neuroendocrine & endocrine secretory granules
• associated with secretory granule membrane via binding to cholesterol-enriched lipid rafts

Alternative splicing

named isoforms=2

Expression

• expressed in brain, heart, kidney, liver, skeletal muscle

Polymorphism

• polymorphisms in the 5'-flanking region & in intron 1 may have an effect on transcriptional activity & be associated with an increase in subcutaneous, but not visceral, fat area
• hence, may influence the risk of obesity

More general terms

• chromogranin; secretogranin;granin

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WXD2.html