apolipoprotein B mRNA editing enzyme complex

Function

• postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA
• apolipoprotein B mRNA editing results in formation of apo B48, rather than apo B100
• catalytic subunit, APOBEC1, binds to the mRNA & deaminate its target cytosine to uracil
• protects the edited APOB mRNA from nonsense-mediated decay

Structure

• subunits include: APOBEC1, ACF

Expression

mRNA editing of apoB occurs in small intestine

More general terms

• molecular complex