microtubule-associated protein 1A/1B light chain 3B (MAP1A/MAP1B LC3 B, MAP1A/1B light chain 3 B, MAP1 light chain 3-like protein 2, autophagy-related protein LC3 B, autophagy-related ubiquitin-like modifier LC3 B, MAP1LC3B, MAP1ALC3)
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Function
- role in formation of autophagosomal vacuoles (autophagosomes)
- one of 3 different subunits that associates with MAP1A & MAP1B
- precursor molecule is cleaved by APG4B/ATG4B to form MAP1LC3B-I
- this is activated by APG7L/ATG7, transferred to ATG3 & conjugated to phospholipid to form MAP1LC3B-II
Structure
belongs to the MAP1 LC3 family
Compartment
- cytoplasm, intracytoplasmic membrane; lipid-anchor
- cytoplasmic vesicle, autophagosome membrane, lipid-anchor
- MAP1LC3B-II binds to the autophagic membranes
Expression
- most abundant in heart, brain, skeletal muscle & testis
- little expression in liver