microtubule-associated protein 1A/1B light chain 3C (MAP1A/MAP1B LC3 C, MAP1A/1B light chain 3 C, MAP1 light chain 3-like protein 3, autophagy-related protein LC3 C, autophagy-related ubiquitin-like modifier LC3 C, MAP1LC3C)

Function

• role in formation of autophagosomal vacuoles (autophagosomes)
• one of 3 different subunits that associates with MAP1A & MAP1B
• the precursor is cleaved by APG4B/ATG4B to form the cytosolic form, MAP1LC3C-I; this is activated by APG7L/ATG7, transferred to ATG3 & conjugated to phospholipid to form the membrane-bound form, MAP1LC3C-II

Structure

belongs to the MAP1 LC3 family

Compartment

• cytoplasm, intracytoplasmic membrane; lipid-anchor
• cytoplasmic vesicle, autophagosome membrane; lipid-anchor
• MAP1LC3C-II binds to the autophagic membranes

Expression

most abundant in placenta, lung & ovary

More general terms

• protein subunit
• autophagy protein (autophagy-related protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4407
• UniProt: http://www.uniprot.org/uniprot/Q9BXW4.html