chondrosarcoma-associated protein 2 (taxol-resistant-associated protein 3, TRAG-3, CSAG2, TRAG3)

Function

• drug-resistance related protein
• expression is associated with the chemotherapy resistant & neoplastic phenotype
• may also be linked to the malignant phenotype

Alternative splicing

named isoforms=2

Expression

weakly expressed in kidney

Pathology

• expressed in various tumor cell lines including carcinomas, myeloid & lymphoid malignancies, melanomas & prostate cancer
• overexpressed in taxol-resistant breast cancer line MDA 435(TR) & the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) & 8226/MDR(10)V

More general terms

• other protein

Additional terms

• chondrosarcoma

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y5P2.html