membrane-associated tyrosine-& threonine-specific cdc2-inhibitory kinase; Myt1 kinase (PKMYT1, MYT1)

Function

• negative regulator of entry into mitosis (G2to M transition)
  • catalyzes phosphorylation CDC2 kinase complexed to cyclin
  • inhibit mitotic entry by cytoplasmic retention of CDC2-CCNB1 complexes
  • negatively regulated by hyperphosphorylation during mitosis
  • phosphorylated by CDC2-CCNB1 complexes, PLK1 protein kinase?
  • hyperphosphorylated form does not associate with CDC2-CCNB1 complexes

Structure

• the membrane-association motif is essential for the localization to membrane of Golgi stack
• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
• contains 1 protein kinase domain

Compartment

• membrane-associated
• Golgi & endoplasmic reticulum

More general terms

• tyrosine kinase (protein tyrosine kinase, PTK)
• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9088
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9088
• OMIM: https://mirror.omim.org/entry/602474
• UniProt: http://www.uniprot.org/uniprot/Q99640.html