STE20-like serine/threonine protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine protein kinase; STE20-related kinase; serine/threonine-protein kinase 2 (SLK, KIAA0204, STK2)

Function

• mediates apoptosis & actin stress fiber dissolution
• proteolytically cleaved by caspase-3
• autophosphorylated
• in vitro, phosphorylates MBP
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 protein kinase domain
• contains 1 UVR domain

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• highest expression in heart, skeletal muscle

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9748
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9748
• UniProt: http://www.uniprot.org/uniprot/Q9H2G2.html