serine/threonine protein kinase BRSK2; brain-specific serine/threonine protein kinase 2; BR serine/threonine protein kinase 2; serine/threonine protein kinase 29; serine/threonine protein kinase SAD-A (BRSK2, C11orf7, PEN11B, SADA, STK29, HUSSY-12)

Function

• serine/threonine protein kinase
• role in polarization of neurons
• phosphorylates MAPT/TAU & WEE1 following phosphorylation & activation by STK11/LKB1
• regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Ser-579
• also regulates neuron polarization by phosphorylation of WEE1 at Ser-642, down-regulating WEE1 in polarized neurons
• activated by phosphorylation on Thr-174 by STK11/LKB1
• phosphorylated on Ser-416
• phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39
• not phosphorylated at Thr-174 by CaMKK2
• in contrast, it is phosphorylated & activated by CaMKK1
• may be inactivated via dephosphorylation of Thr-174 by PP2C
• may be phosphorylated at Thr-260 by PKA

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
• contains 1 protein kinase domain
• contains 1 UBA domain

Alternative splicing

named isoforms=5

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9024
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9024
• OMIM: https://mirror.omim.org/entry/609236
• UniProt: http://www.uniprot.org/uniprot/Q8IWQ3.html