Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22, ARHGAP22, RHOGAP2)

Function

• Rho GTPase-activating protein
• role in signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis
• GTPase activator for RAC1 by converting it to an inactive GDP-bound state
• inhibits RAC1-dependent lamellipodia formation
• role in transcription regulation via interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter
• interacts with VEZF1

Structure

• contains 1 PH domain
• contains 1 Rho-GAP domain

Compartment

• cytoplasm, nucleus
• mainly cytoplasmic, some fraction is nuclear

Alternative splicing

named isoforms=4

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z5H3.html