SLIT-ROBO Rho GTPase-activating protein 1; srGAP1; Rho GTPase-activating protein 13 (SRGAP1, ARHGAP13, KIAA1304)

Function

• GTPase-activating protein for RhoA & Cdc42 small GTPases
• together with CDC42 seems to be involved in the pathway mediating repulsive signaling of Robo & Slit proteins in neuronal migration
• SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 & inactivates CDC42
• interacts with ROBO1, CDC42 & RHOA
• interacts with FASLG

Structure

• contains 1 FCH domain
• contains 1 Rho-GAP domain
• contains 1 SH3 domain

Alternative splicing

named isoforms=2

Expression

expressed in brain, lung, kidney, & testis

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57522
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57522
• OMIM: https://mirror.omim.org/entry/606523
• UniProt: http://www.uniprot.org/uniprot/Q7Z6B7.html