roundabout homolog 1 (H-Robo-1, deleted in U twenty twenty, ROBO1, DUTT1)

Function

• receptor for SLIT1 & SLIT2
• molecular guidance in cellular migration
  • axonal navigation at the ventral midline of the neural tube
  • projection of axons to different regions during neuronal development
• in axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex
• lung development ?

Structure

• belongs to the immunoglobulin superfamily, ROBO family
• contains 3 fibronectin F3 modules
  • contains 5 Ig-like C2-type domains (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

widely expressed, with exception of kidney

Pathology

• defects in ROBO1 may be a cause of breast cancer & small cell lung cancer

More general terms

• membrane protein
• receptor
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602430
• UniProt: http://www.uniprot.org/uniprot/Q9Y6N7.html