Slit homolog 1 protein; Slit-1; multiple EGF-like domains protein 4 (SLIT1, KIAA0813, MEGF4, SLIL1)

Function

• thought to act as molecular guidance cue in cell migration
  • function appears to be mediated by interaction with roundabout homolog receptors
• during neural development involved in axonal navigation at the ventral midline of the neural tube & projection of axons to different regions (putative)
• SLIT1 & SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb
• interacts with ROBO1 & GREM1 (putative)

Structure

• contains 1 CTCK (C-terminal cystine knot-like) domain
• contains 9 EGF-like domains
• contains 1 laminin G-like domain
• contains 20 LRR repeats (leucine-rich repeats)
• contains 4 LRRCT domains
• contains 4 LRRNT domains

Compartment

secreted (putative)

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in adult forebrain
• expressed in fetal brain, lung & kidney

More general terms

• slit homolog protein
• multiple epidermal growth factor like domains (protein)
• leucine-rich repeat-containing protein (LRRC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6585
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6585
• OMIM: https://mirror.omim.org/entry/603742
• UniProt: http://www.uniprot.org/uniprot/O75093.html