SH3 domain-binding protein 1; 3BP-1 (SH3BP1)

Function

• putative GTPase activating protein by homology with p160BCR & rho-GAP
• binds to SH3 domain of abl, src & grb2.
• shows GAP activity for Rac-related proteins
  • no GAP activity for Rho-related proteins or Ras-related proteins
• inhibits PDGF-induced membrane ruffling mediated by Rac (putative)

Structure

• contains 1 BAR domain
• contains 1 Rho-GAP domain

Alternative splicing

named isoforms=2

More general terms

• rho GTPase-activating protein (rho-GAP)
• SH3 domain-binding protein
• phosphoprotein

Additional terms

• src homology 3 [SH3] domain

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23616
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23616
• UniProt: http://www.uniprot.org/uniprot/Q9Y3L3.html