histone H2B type 1-C/E/F/G/I; histone-H2B.1A; H2B.a/g/h/k/l; H2B.1 A; H2B/a; H2B/g; H2B/h; H2B/k; H2B/l (HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2B, H2BFG, HIST1H2BG, H2BFA, HIST1H2BI, H2BFK)

Function

• core component of nucleosome
• has broad antibacterial activity
• may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, & to the bactericidal activity of amniotic fluid
• monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation & is also prerequisite for histone H3 Lys-4 & Lys-79 methylation
• also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase 2
• phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation
• phosphorylated on Ser-15 in response to DNA double-strand breaks, & in correlation with somatic hypermutation & immunoglobulin class-switch recombination

Structure

belongs to the histone H2B family

Compartment

nucleus

More general terms

• histone-H2B

Database

• UniProt: http://www.uniprot.org/uniprot/P62807.html
• OMIM: https://mirror.omim.org/entry/602798
• OMIM: https://mirror.omim.org/entry/602804
• OMIM: https://mirror.omim.org/entry/602805
• OMIM: https://mirror.omim.org/entry/602807
• OMIM: https://mirror.omim.org/entry/602847