transcriptional enhancer factor TEF-5; DTEF-1; TEA domain family member 3; TEAD-3 (TEAD3, TEAD5, TEF5)

Function

• transcription factor
• role in the Hippo signaling pathway, a pathway involved in organ size control & tumor suppression
• mediates expression of YAP1 & WWTR1/TAZ, thus regulating cell proliferation, migration & epithelial mesenchymal transition (EMT) induction.
• binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
• interacts with YAP1 & WWTR1/TAZ

Structure

• contains 1 TEA DNA-binding domain

Compartment

nucleus

Expression

• preferentially expressed in the placenta

More general terms

• TEA domain family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7005
• OMIM: https://mirror.omim.org/entry/603170
• UniProt: http://www.uniprot.org/uniprot/Q99594.html