HMG box-containing protein 1 (HMG box transcription factor 1, high mobility group box transcription factor 1, HBP1)

Function

• transcriptional repressor
• binds to the promoter region of target genes
• regulation of the cell cycle
• regulation of Wnt pathway
• binds preferentially to 5'-TTCATTCATTCA-3
• binding to the H1F0 promoter is enhanced by interaction with RB1
• disrupts the interaction between DNA & TCF4
• binds the 2nd PAH repeat of SIN3A
• binds TCF4 & RB

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• transcriptional silencer (transcriptional repressor)
• HMG box transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/O60381.html